Superfood τα σταφύλια: Ωφελούν και το δέρμα [μελέτη]

Tuesday, May 26, 18:00 CESTImaging skin squamous cell carcinoma in the head and neckSpeaker: Alexandra Borges, Lisbon/PT | Moderator: Ayça Akgoz Karagosmanoğlu, Ankara/TRGeneral description, scope and objectives of this webinarThe programme of this webinar will cover imaging skin squamous cell carcinoma in the head and neck. It is aimed at head & neck radiologists, radiologist residents/juniors, students and people who are interested in the ESHNR diploma who want to improve their skills in:– Staging and follow-up of skin squamous cell carcinoma of the head and neck– Use of US imaging for local and lymphatic staging– Use of MRI to depict perineural spread in risk areasAfter watching the webinar, participants will be able to– Recognize high risk SCC of the skin in the head and neck area– Select appropriate imaging techniques for staging and follow-up– Understand the impact of imaging in patient’s management and prognosis

OverviewPreterm birth is associated with an increased risk of respiratory complications that can have serious consequences also in the middle- and long-term. Recently, increasing awareness has emerged that chronic lung disease of prematurity (CLDP) may persist throughout the lifespan, representing the earliest and most prolonged chronic respiratory disease. Since CLDP represents a continuum of different diseases, including airway obstruction, alveolar and pulmonary vascular underdevelopment, which may not all be present in all patients at all times, it has been recently proposed that the novel treatable trait approach described for adult airway disease can also be applied to CLDP, guiding a precision medicine approach to its management across the lifespan. Definition, identification, and treatment of the treatable traits as early as possible can change the disease trajectory.It is important to cover this topic because there is often a lack of communication and poor knowledge sharing between:neonatologists who are aware of the early origins of CLPD but often do not consider the long-term consequences of this condition;paediatricians and paediatric pulmonologists who follow up and manage children with CLPD;adult pulmonologists who often ignore the early origins of their patient's chronic conditions.Educational aims:The webinar aims to:Introduce the concept of treatable traits to neonatologists and paediatric pulmonologists, with particular focus on those caring subjects born preterm, and to explore how this approach can be applied in childhood and adolescence.Increase awareness among adult pulmonologists of the specific respiratory and extra-pulmonary treatable traits that characterise adults born preterm with chronic lung disease, and how these differ from other chronic airway diseases.Demonstrate how defining respiratory and extra-pulmonary treatable traits can support the development of personalised, structured and multidisciplinary follow-up pathways, promoting a holistic, patient-centred approach across the lifespan.Topics:Respiratory treatable traits in preterm-born individuals in the pediatric ageWhat is known about treatable traits in patients with respiratory diseases in general, treatable traits in preterm-born individuals in adult age, and comparison between the conditionsExtrapulmonary treatable traits of former preterm infants: how to structure a multidisciplinary follow-up programmeFormatOne-hour webinar structured as follows:Opening remarks - Introduction by Chairs (2 min)Presentation 1: Respiratory treatable traits in preterm-born individuals in the paediatric age - Marielle Pijnenburg (14 min)Presentation 2: Respiratory treatable traits in preterm-born individuals in the adult age - Rosa Faner (14 min)Presentation 3: Extrapulmonary treatable traits of former preterm infants - Luca Bonadies (14 min)Live Q&A and round table - moderated by Chairs (15 min)Wrap-up (1 min)Learning outcomesFollowing this webinar, participants will be able to:Integrate knowledge of early-life aetiology, endotypes and developmental mechanisms to interpret long-term lung function trajectories and respiratory outcomes in individuals with chronic lung disease of prematurity.Incorporate respiratory and extra-pulmonary comorbidities into a unified, lifespan-oriented clinical assessment framework.Apply the treatable traits approach to identify, prioritise and manage modifiable traits in routine clinical practice.Implement strategies to enhance coordination and handover between neonatal, paediatric and adult respiratory services, and develop structured, multidisciplinary follow-up pathways tailored to individuals born preterm.CME creditAn application for accreditation of this webinar has been made to the European Board for Accreditation in Pneumology (EBAP) for 1 CME credit per 1-hour attendance. If accredited, the CME credit will be granted upon attendance of at least 60 minutes during the live webinar only.What is a webinar?A webinar closely simulates a lecture-based teaching experience. The speaker can interact with the audience, just as in a classroom setting. During the webinar, you will be asked to share your opinion on issues related to the topic using interactive polls.All participants will be able to hear the lecturer and see the slides throughout the presentation. As a participant you will be able to pose questions or discuss ideas with the other participants via the text chat facility and the speaker will respond to the questions via the microphone.

Cancer evolution is a multi-faceted process and a major clinical challenge. Indeed, tumors constantly change as they progress through multiple mechanisms, the understanding of which is critical to anticipate disease phenotypes and responses to therapy.This EMBO Workshop will bring together an interdisciplinary community of scientists to facilitate discussion and collaboration on genetic and non-genetic mechanisms of cancer evolution. We will explore a wide spectrum of oncogenic drivers and molecular data types, with a focus on their impact across the three main phases of cancer evolution: initiation, progression, and relapse. This choice was driven by some of the most exciting findings in the last few years exploring, e.g., cancer-associated genetic and non-genetic alterations in normal cells (field cancerization), emerging technologies to monitor tumor progression and response to therapy (e.g., liquid biopsies), and the preponderant role of cell plasticity and lineage reprogramming in therapeutic resistance.Cancer evolution is a multifaceted problem, and as such, a prism of complementary ideas is needed to understand and harness this process.

Funded by EMBO for excellence in the life sciencesThis course will take place at EMBL Grenoble.Course overviewRecent advances in cryo-electron microscopy/tomography (cryo-EM/ET), super-resolution microscopy, and deep-learning-based protein structure prediction, combined with increasingly sophisticated sample preparation methods, have transformed structural biology. Solving the field’s most complex challenges will require researchers who can strategically integrate these powerful tools.This course provides a comprehensive overview of modern structural biology methods, with emphasis on sample preparation, characterisation, and data integration.Key topics include:Multi-subunit protein expression in bacterial, insect, and mammalian systemsIsolation of native complexesIn vitro reconstitution of protein and protein–nucleic acid assembliesBiochemical and biophysical approaches to assess stoichiometry and homogeneityThis latest edition of this long-standing course features a refreshed lineup of speakers and topics, highlighting the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. The programme aims to equip participants with the theoretical and practical skills needed to combine complementary approaches and apply them to contemporary structural biology research.AudienceAdvanced PhD students and postdocs, currently working on challenging projects in structural biology that would benefit form hybrid approaches.Learning outcomesParticipants will learn 3D structure determination of macromolecular assemblies at various resolution scales, and strategies to integrate data from X-ray crystallography, cryo-EM, SAXS, NMR, mass spectrometry, smFRET, and super-resolution microscopy.What past participants say about the course“The course on Structural Characterisation of Macromolecular Complexes was very engaging, with lecturers eager to learn about our projects and providing valuable insights. I also especially appreciated the opportunity to meet fellow students from all over the world.” —Sophie Roth, Harvard University, USA“It was a wonderfully intense experience. I learned more than I thought was possible in a single week.” — Marta Gapinska, University of Warsaw, Poland