Η καταστολή της όρεξης από τους αγωνιστές GLP-1 οφείλεται κυρίως σε κεντρικούς μηχανισμούς δράσης και όχι στην καθυστέρηση της γαστρικής κένωσης

Conference SummarySince 1985, this conference has been the premier international meeting devoted exclusively to the study of genetic recombination and genomic rearrangements. Recombination is a fundamental DNA repair process that plays essential roles in the replication, maintenance, preservation, evolution, and transmission of the genome. Originally centered on meiosis, the field has expanded dramatically to encompass the essential role of recombination in maintaining genome integrity across all cell types. Its implications also apply to the study of DNA repair, especially in response to environmental stressors and chemotherapeutic agents. This year’s program will focus on the mechanisms of recombination in various cellular contexts, genome instability, and the links between recombination and aging, as well as its connection to human diseases, especially cancer. The conference will bring together scientists at all career stages who investigate diverse aspects of recombination and genome maintenance, using a wide range of biological systems and experimental approaches. The agenda will feature a broad array of keynote lectures, platform presentations, panel discussions, and numerous opportunities for short talks and networking.Attendees will learn about:• Mechanisms of homologous recombination, from initiation to completion.• Genome rearrangements, specifically regarding mechanisms and consequences.• The interplay between recombination and other cellular processes.Program Topics• Molecular mechanisms that underpin each step in the recombination reaction• Telomere metabolism and maintenance mechanisms in cancer• Genome rearrangements, including chromothripsis and their links to tumorigenesis• Replication- and transcription-associated recombination• Regulation of recombination by post-translational protein modification• The role of chromatin structure in recombination and DNA damage signaling• Meiotic recombination, gamete quality, and fertilityWorkshopsA series of Meet the Expert sessions will be held. Early-career scientists will be matched with experienced professionals for informal, focused conversations on scientific topics, research strategies, and career advice. The Career Development Workshops will feature interactive panel discussions on academic and non-academic career paths. This will include meetings with researchers from industry, biotech, and scientific publishing to provide mentorship, practical guidance, and support for the next generation of researchers.

Designed for young urologists with an academic profile, this week-long masterclass is a high-level programme on general urology. The ESU-Weill Cornell Masterclass in General urology is a collaborative programme between the European School of Urology and Weill Medical College of Cornell University.

General infoThe world's first validated training curriculum in urological robotic surgery!Are you a robot-naïve urology fellow, resident or urologist eager to master robotic surgery? This 5-day intensive course at Orsi Academy will give you the skills and confidence to performe a robot-assisted radical prostatectomy independently and effectively. What to expectHands-on training for basic and procedural skills on live animal tissueInteractive theoretical lecturesLive surgery broadcast for real-life insightsA proven proficiency-based progression methodology, ensuring you acquire not just knowledge, but true surgical competence What you will learnDevelop robotic skills: Gain hands-on experience and master the fundamental techniques of robot-assisted prostatectomy through structured, proficiency-based training.Translate skills in to clinical practice: you will learn to perform robotic urological procedures safely and effectively. Tailored to your progressIf you do not reach proficiency level by the end of the 5th day, an additional remediation day will be arranged at no extra course fee (travel & accommodation costs excluded). Exclusive benefit for EAU membersMembers of the European Association of Urology (EAU) receive a 15% discount on the course fee with the code EAUMEMBER2026. A valid EAU membership ID is required.

Chronic cough is a common condition that affects up to 10% of adults and, not surprisingly, is encountered by healthcare workers in all fields of clinical practice.Chronic cough can coexist with or without pulmonary and extrapulmonary conditions and can be refractory to therapies that generally improve these associated conditions.Often chronic cough is not associated with any detectable disease. The basis of chronic cough is now attributable to a state of cough hypersensitivity characterised by increased cough responses to stimuli that affect the airways and vagally innervated tissues as well as by excessive cough responses to innocuous stimuli.This may be caused by neuroinflammatory and neuropathic mechanisms at both peripheral and central levels. This new concept of chronic cough has impacted on our approach to diagnosis and management. The management of chronic cough starts with the exclusion of associated conditions, followed by use of speech and language therapy and of neuromodulators.There is increasing interest in developing new antitussive neuromodulators with the introduction of blockers of the ATP receptor P2X3 in the clinic. With this significant progress in our understanding of mechanisms and new treatments, chronic cough is now being considered a disease entity of its own.